Executive producer David Michael Latt announced on Twitter that the show is ending after five seasons.
Hit shows such as Teen Wolf and Legion will return to Comic-Con, along with new shows Ghosted, Inhumans and many more.
SyFy will be celebrating its 25th Anniversary at Comic-Con 2017, with a Battlestar Galactica reunion, along with 15 panels and screenings.
Debuting this fall on Syfy, Z Nation is set three years after the zombie apocalypse, as a group of heroes search for a cure.
Michael Welch and Kellita Smith have joined the ensemble zombie drama Z Nation for Syfy, following a team of heroes transporting the last survivor from New York to California.
The 13-episode horror series will take place three years after a zombie virus has spread throughout the world.