I think it's fair to say that most of us would be sad losing out on the chance to make a million dollars. Imagine losing out on making 70 million. Rob Lowe was on WTF podcast with Marc Maron lamenting about just that: losing out on 70 million dollars. Rob turned down the now iconic role of "McDreamy" in the massive hit Shonda Rhimes TV show Grey's Anatomy. That cost him big. Rob told prolific podcast comedian Marc Maron on Monday.

"Dude, I turned down Grey's Anatomy to play McDreamy. That probably cost me $70 million dollars!"

The Grey's Anatomy doctor we all now know as McDreamy was almost done by the Parks and Recreation star, a fact that the actor revealed first back in his 2014 memoir. Instead of doing Grey's, Lowe chose to do a show called Dr. Vegas whose disastrous 2004 production run ended when it was pulled after just five episodes. Patrick Dempsey, meanwhile ended up doing the McDreamy role Lowe turned down for 11 solid years earning him a gigantic stack of money.

In the time frame Rob Lowe is referencing, Rob was trying to decide whether to do Grey's or Dr. Vegas. Lowe was already near the end of locking down the Dr. Vegas deal when he got a call from a new show called Grey's Anatomy. "After a week of negotiating, my deal was done, although not yet signed. It was then that I got an urgent call from the producers of a potential new show for ABC called Grey's Anatomy. I agreed to meet with the people making Grey's Anatomy. I had read it and loved it-the writing was crisp, real and very entertaining-and it's always been a good idea to hear out talented people."

Rob was promised the role of Derrick from the very start of everything, with no one else in mind to do the part. He was beyond torn apart about which show to go with. "Grey's was a much better script; in fact, there was no comparison," he said, but... "Year after year after year, all of ABC's new dramas flopped. CBS was on a hot streak that continues to this day. Although Grey's was a much better script, I chose Dr. Vegas. The odds were just too stacked."

RELATED: Grey's Anatomy Star Jason George Moves to Firefighter Spin-Off

Rob does not harbor any regret for not taking the part. It wasn't long after the show came out that he realized that he had made the right decision when he passed on the role: "At the end of the day it was like, I watched it when it came out. And when they started calling the handsome doctor 'McDreamy,' I was like, 'Yeah, that's not for me.'"

The Virginia-born, Malibu-raised actor just recently celebrated his 55th birthday with his sons and his wife that has been with him for 27 years, retired make-up artist Sheryl Berkoff. Marc and Rob had a lot to talk about, you can hear it at WTF Podcast.