Comedy superstars Patton Oswalt and Glenn Howerton have signed on to star in an untitled high school comedy pilot that is set up at NBC, through writer Mike O'Brien (Saturday Night Live). NBC's Late Night host Seth Meyers is serving as an executive producer alongside the writer and Saturday Night Live creator Lorne Michaels. The project was originally titled AP Bio, but the producers are currently seeking a new title for the pilot.

TV Line reports that the series centers on Glenn Howerton's character Jack, described as a "hilariously cynical Ivy League professor" who takes a job teaching AP Biology after losing his dream job. This teacher begins to impose an unusual teaching style, using his students to help enact a plot of revenge against those who have wronged him throughout his life. Patton Oswalt will be playing Jack's boss Principal Durbin, who strives to be the "cool, chill" principal, even though that goes against his very nature.

Mike O'Brien is writing the pilot script, and he will also serve as an executive producer alongside Seth Meyers and Lorne Michaels, Mike Shoemaker and Andrew Singer. The show will be produced through the Universal TV studio, which will also produce alongside Lorne Michael's company Broadway Video. If the show does make it to series, it could have some sort of an impact on FX's It's Always Sunny in Philadelphia, which Glenn Howerton co-created, writes, produces and stars on.

It's Always Sunny in Philadelphia has already been renewed for two more seasons on FXX, but one of the show's stars, Kaitlin Olson, recently got her own broadcast comedy show as well with Fox's The Mick, which has already been picked up for a second season. While Kaitlin Olson is still expected to return for It's Always Sunny in Philadelphia, Glenn Howerton's involvement may be more limited, since he serves as not only a star, but also as a writer and producer. This new untitled project hasn't been given a series order yet, but if it does get picked up, it could signal a minor shake-up of sorts at It's Always Sunny in Philadelphia, but that's only speculation at this point.

Patton Oswalt has served as the narrator for ABC's The Goldbergs throughout it's run, and he has recently appeared in guest-starring roles on Netflix's Santa Clarita Diet, The Simpsons, Crazy Ex-Girlfriend, Mystery Science Theater 3000 and Agents of S.H.I.E.L.D.. Aside from starring on It's Always Sunny in Philadelphia, Glenn Howerton has also had guest-starring roles on House of Lies, The Mindy Project, Family Guy and the first season of FX's Fargo. Hopefully we'll have more on this Untitled Mike O'Brien Project soon.