Amazon Studios, the original movie and series production arm of, today announced that Cynthia Nixon (Sex and the City), Amy Sedaris (Strangers with Candy), Wanda Sykes (Curb Your Enthusiasm), and Julie White (Go On) will appear in the Amazon Original Series Alpha House, written by Doonesbury creator, Garry Trudeau. Alpha House, currently filming in New York, will air exclusively on Prime Instant Video later this year. This all-star female cast joins Alpha House alums John Goodman, Clark Johnson, Matt Malloy, and Mark Consuelos.

Alpha House follows four Republican senators-turned-housemates, Gil John Biggs (John Goodman), Robert Bettencourt (Clark Johnson), Louis Laffer (Matt Malloy) and, Andy Guzman (Mark Consuelos) through re-election battles, looming indictments, parties and housemate drama. Nixon will play Senator Carly Armiston, the formidable, confident, Democratic senator from New York. She is joined by Sedaris, who will play Louise Laffer, the sweet, concerned wife of Senator Louis Laffer. Sykes will play Senator Rosalyn DuPeche, a strong-willed, funny Democrat who just happens to be a neighbor of the male senators, while White will play the tough, determined, yet charming southern wife to Goodman's character Gil John Biggs.

Here's a statement from series creator Garry Trudeau, who worked with Nixon on his celebrated show, Tanner '88 and has long admired the work of Sykes, Sedaris and White.

"We're lucky enough to have four of the most talented performers around joining the show."

Following a positive response from Amazon customers, Alpha House was one of five pilots selected from Amazon Studios' first set of 14 pilots, which debuted in April. Of the 14 pilots, Alpha House, Betas, Annebots, Creative Galaxy and Tumbleaf were chosen, with the help of customer feedback, to become full series. The shows will stream on Prime Instant Video later this year and in early 2014.